Sparse Principal Component Analysis for Identifying Ancestry-Informative Markers in Genome-Wide Association Studies
نویسندگان
چکیده
منابع مشابه
Accounting for ancestry: population substructure and genome-wide association studies.
Accounting for the genetic substructure of human populations has become a major practical issue for studying complex genetic disorders. Allele frequency differences among ethnic groups and subgroups and admixture between different ethnic groups can result in frequent false-positive results or reduced power in genetic studies. Here, we review the problems and progress in defining population diff...
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ژورنال
عنوان ژورنال: Genetic Epidemiology
سال: 2012
ISSN: 0741-0395
DOI: 10.1002/gepi.21621